The IsoClean® is a portable, self-contained high efficiency particulate air (HEPA) filtration system designed to easily and economically create a negative pressure isolation room that will meet OSHA and CDC TB guidelines. The IsoClean® can be used as a positive pressure clean air recirculating system in clinics, waiting rooms, hospital emergency rooms and other confined areas or as a partial or complete exhausting system to create a negative pressure isolation room for possible use with patients known or suspected of having TB, SARS or other infectious diseases.